According to Margo Harrison, the 1911 invention of Midol was the last time a new period pain product hit the market. That was until last week, when her company, Wave Bye, launched its line of supplements to promote cycle regularity and help curb bleeding and cramps. “(Women) are not trying to be s uperhuman,” the OB-GYN said. “They just want to feel normal.” Wave Bye, which Harrison founded in 2023, sells a “backbone” daily supplement called Bye Irregularity to make periods more predictable. Those are intended to treat several symptoms, including potential migraines, fatigue and irritability that come from premenstrual syndrome. Once you know your schedule, the company’s period-specific products, called Bye Cramps and Bye Bad Cramps, are more effective, she said.  They prevent messengers from telling the uterus to contract and bleed, she added. “You need to take the supplement every day to regulate your cycle, and then what differentiates our (other) products is they need to be taken two days before bleeding,” Harrison explained. “If you block symptoms two days before, you totally change the period experience.” Other medications and remedies are sparse, Harrison said. Though women will use Midol and Tylenol for relief, those pills target the brain rather than the uterus directly, she said. There are also gummies on the market for PMS, but she added that there’s nothing like Wave Bye’s two-pronged, premenstrual attack on irregularity and period pain using its Vitamin E-based product. Heating pads and relief patches only do so much, too, Harrison added. She hopes that Wave Bye can be a more encompassing approach to the menstruation problem about half the population manages for decades of their lives. The company sells the products in four bundles — each for different severities of symptoms – on its website. They cost between $70 and $80 on a monthly subscription, with one-time purchases and three-month and 12-month packs also available. Harrison is also in negotiations to sell Wave Bye at yoga studios and health shops including Bridget’s Botanicals in Littleton. The company also offers revenue sharing or discount opportunities for health care professionals such as OB-GYNs and nurses. “There’s no benefit from bleeding just to bleed. If you cut your hand, are you supposed to just let it keep bleeding? You’re not getting any benefit from not turning off the faucet,” Harrison said. “It’s not necessarily bad – it’s meant to support a pregnancy. But we want to reduce period pain and bleeding and make that period experience better in order to give people their time back.” Harrison was a clinical researcher at Columbia University and the University of Colorado Anschutz, focusing on pregnancy in poor countries. She then went to consult VC-backed women’s health firms three years ago. Through that and her work as an abortion provider for Planned Parenthood of the Rocky Mountains over the last two-and-a-half years, she saw the need for Wave Bye. “I’d have patients sit up from an abortion and hear them say, ‘Well, at least that was less painful than my period,’” she said. “People get gaslit, and the OB-GYNs don’t deal with period pain until it’s really profound. It feels like there’s this gap. They just do what their moms or friends or community are doing.” Wave Bye has so far raised $300,000 out of what Harrison hopes is an $875,000 round. Most of that is angel funding, she said, along with one Denver-area institutional investor. She hopes to close the round in the next couple of months. The money will mostly be used to develop another product, which Harrison said will likely take at least two years, and continue work on a yet-to-be-released app to help users schedule their doses. Related Articles Health | Can technology help more survivors of sexual assault in South Sudan? Health | A political reporter takes her scoops to YouTube Health | One Tech Tip: Wasting too much time on social media apps? Tips and tricks to curb smartphone use Health | KSL exec lists Tudor on Cranmer Park for $5M Health | Portillo’s eyes two more Colorado locations for expansion Wave Bye already saw some traction from a small batch of users late last year, so Harrison is confident sales will take off now that her business is officially off the ground. Of the 25 units Wave Bye has sold, she said about half came from three- and 12-month purchases. “If people trust the product,” she said, “they’re gonna get more.” Get more business news by signing up for our Economy Now newsletter. ...read more read less