.................... LOS ANGELES (KTLA) - The worst-case scenario has been realized in the Pacific Palisades neighborhood of Los Angeles, where an estimated 1,000 structures, many of them homes, have been destroyed by a Santa Ana-wind-fueled wildfire, authorities confirmed on Wednesday morning. The Palisades Fire was first reported around 10:30 a.m. Tuesday in the 1100 block of North Piedra Morada Drive. By Wednesday afternoon, the fire had exploded to 15,832 acres with no containment. At a news conference Wednesday morning, L.A. County Fire Chief Anthony Marrone revealed an estimated 1,000 structures had been lost. There was also a "high number of people who didn't evacuate" who suffered serious injuries, he said. MALIBU, CA - January 08: Firefighters continue to battle wind and fire as homes go up in flames in Malibu along Pacific Coast Highway near Carbon Canyon Road in the Palisades Fire on Wednesday, January 8, 2025 (Photo by David Crane/MediaNews Group/Los Angeles Daily News via Getty Images)The Palisades fire burns as seen from Baldwin Hills Scenic Overlook in Los Angeles on January 8, 2025. A ferocious wildfire in a Los Angeles suburb devoured buildings and sparked panicked evacuations January 7, as hurricane-force winds tore through the region. More than 200 acres (80 hectares) was burning in Pacific Palisades, a upscale spot with multi-million dollar homes in the Santa Monica Mountains. Across town, on the northern edge of Los Angeles, another fire broke out in Eaton Canyon, near Pasadena, quickly consuming 200 acres (81 hectares) later in the night, according to Angeles National Forest officials. (Photo by Agustin PAULLIER / AFP) (Photo by AGUSTIN PAULLIER/AFP via Getty Images)The Palisades Fire ravages a neighborhood amid high winds in the Pacific Palisades neighborhood of Los Angeles, Wednesday, Jan. 8, 2025. (AP Photo/Damian Dovarganes)The Palisades Fire ravages a neighborhood amid high winds in the Pacific Palisades neighborhood of Los Angeles, Tuesday, Jan. 7, 2025. (AP Photo/Ethan Swope)Flames rise as the Palisades Fire advances on homes in the Pacific Palisades neighborhood of Los Angeles, Tuesday, Jan. 7, 2025. (AP Photo/Ethan Swope)Will Adams watches as flames from the Palisades Fire close in on his property in the Pacific Palisades neighborhood of Los Angeles, Tuesday, Jan. 7, 2025. (AP Photo/Ethan Swope)Water is dropped on the advancing Palisades Fire by helicopter in the Pacific Palisades neighborhood of Los Angeles, Tuesday, Jan. 7, 2025. (AP Photo/Ethan Swope)Plumes of smoke are seen as a brush fire burns in Pacific Palisades, California on January 7, 2025. (Getty Images)Plumes of smoke are seen as a brush fire burns in Pacific Palisades as seen from Santa Monica, California on January 7, 2025. (Getty Images)View of the Palisades Fire from LAX on Jan. 7, 2025. (KTLA)A palm tree is seen burning during the Palisades Fire in Los Angeles on Jan. 7, 2025. (KTLA)A firefighter tries to extinguish a fire as it damages a property in the Pacific Palisades neighborhood of Los Angeles Tuesday, Jan. 7, 2025. (AP Photo)A firefighter battles the Palisades Fire as it burns a structure in the Pacific Palisades neighborhood of Los Angeles, Tuesday, Jan. 7, 2025. (AP Photo/Ethan Swope)A firefighter jumps over a fence while fighting the Palisades Fire in the Pacific Palisades neighborhood of Los Angeles, Tuesday, Jan. 7, 2025. (AP Photo/Ethan Swope)The Palisades Fire burns a residence in the Pacific Palisades neighborhood of Los Angeles, Tuesday, Jan. 7, 2025. (AP Photo/Ethan Swope)A vehicle and other structures are burned as the Palisades Fire ravages a neighborhood amid high winds in the Pacific Palisades neighborhood of Los Angeles, Wednesday, Jan. 8, 2025. (AP Photo/Damian Dovarganes)The Palisades Fire ravages a neighborhood amid high winds in the Pacific Palisades neighborhood of Los Angeles, Wednesday, Jan. 8, 2025. (AP Photo/Damian Dovarganes) Daylight brought the extent of the devastation into clear focus as entire neighborhoods and commercial centers were leveled in this affluent coastal community. With 1,000 structures destroyed, the Palisades Fire is already far more destructive than the second-most destructive wildfire in Los Angeles history, according to statistics kept by the Wildfire Alliance, the Associated Press reported. The last most destructive fire was the Sayre Fire in November 2008, which destroyed 604 structures in Sylmar. Evacuations were ordered for the entire Pacific Palisades area down to the Pacific Ocean. The evacuations, which also included warnings for Santa Monica and Calabasas areas, impacted tens of thousands of homes and businesses. An evacuation shelter for people and pets was established at the Westwood Recreation Center at 1350 S. Sepulveda Blvd. A CalFire map showing the perimeter of the Palisades Fire in Los Angeles and evacuation zones. 12:30 p.m. on Jan. 8, 2025. (CalFire) Santa Monica and Las Virgenes unified school districts canceled classes Wednesday. Dozens of Los Angeles County schools were closed Wednesday due to the fire. A number of schools in the Los Angeles Unified School District were also closed. The cause of the fire remains under investigation. Pacific Palisades is located about 10 miles from Malibu, where the Franklin Fire burned more than 4,000 acres and burned several homes after erupting during similar windy conditions in December. Palisades Fire Resources: LAFD Alerts | CALFIRE Incident Page | LAFD on X The Associated Press contributed to this report.