A new study has uncovered how an exceptionally scarce protein can orchestrate the assembly of large-scale gene-silencing structures inside cells, and what happens when that process breaks down. The findings, published today in Molecular Cell, identify a self-clustering mechanism in the Polycomb prot ein CBX2 that is essential for initiating the formation of gene-repressive condensates and guiding stem cells toward their proper fates. ...read more read less