For successful cell division, chromosomal DNA needs to be packed into compact rod-shaped structures. Defects in this process can lead to cell death or diseases like cancer. A new study has shown how chromosomes change shape during cell division. Certain protein complexes help fold DNA into overlappi ng loops that repel each other, which then stack to create a rod-like structure. This is the first time scientists have directly observed an entire chromosome in high resolution within a dividing cell, offering new insights into how chromosomes are formed. ...read more read less