Four astronauts rocketed into orbit Friday evening on their way to the International Space Station. NASA astronauts Anne McClain and Nichole Ayers, Japanese astronaut Takuya Onishi and Russian cosmonaut Kirill Peskov lifted off at 7:03 p.m. ET from NASA’s Kennedy Space Center, roaring into pris tine blue skies over Florida roughly 48 hours after a first launch attempt was scrubbed. “This mission is a testament of what humans can achieve when we work together. Go Crew-10,” Ayers radioed to mission control in the final minutes of a smooth countdown. The flight, a mission known as Crew-10, was part of NASA’s regular rotation of crew members to and from the space station. But it has attracted more attention than usual because it means NASA astronauts Suni Williams and Butch Wilmore are finally closing in on their long-awaited flight back to Earth. Crew-10 mission Roscosmos cosmonaut Kirill Peskov, NASA astronauts Nichole Ayers and Anne McClain and JAXA astronaut Takuya Onishi at the Kennedy Space Center on Wednesday. (Gregg Newton / AFP / Getty Images) Williams and Wilmore have been in the spotlight for months because of the unusual circumstances of their time in orbit. The pair was expected to stay at the space station for just a week as part of the first crewed test flight of Boeing’s Starliner spacecraft in June, but problems with the vehicle forced them to remain at the orbiting outpost. The new crew will relieve Williams, Wilmore and two others — NASA astronaut Nick Hague and Russian cosmonaut Aleksandr Gorbunov — who are wrapping up a roughly six-month stint at the space station. The Crew-10 astronauts rode into orbit atop a SpaceX Falcon 9 rocket. Roughly 10 minutes after liftoff, the booster’s reusable first stage successfully returned to Earth, landing back at the Cape Canaveral Space Force Station in Florida. “It was an honor flying with you this evening,” SpaceX’s flight director radioed to the crew in orbit. “We wish you well on your journey and give Crew-9 our best.” The Crew-10 astronauts will now spend more than 28 hours in low-Earth orbit journeying to the space station. They are expected to arrive at the orbiting outpost late on Saturday. After that, the outgoing crew could depart as early as Wednesday, March 19, according to NASA. The space station has seen the arrival of more than 270 people. NASA astronauts Butch Wilmore and Suni Williams arrived on June 6. (NASA) The scrubbed launch attempt this week added to the drama of the situation. It was called off on Wednesday with just over 40 minutes remaining in the countdown clock, because of an issue with one of the ground systems at the launch pad. The four astronauts were already strapped inside the Dragon capsule when the decision was made. The Crew-10 group is made up of a mix of veterans and first timers. McClain and Onishi will be visiting the space station for the second time, while Ayers and Peskov are on their first spaceflight. All four astronauts share a common background as pilots. Their arrival at the space station will kick off a handover period that typically lasts a couple days to allow the new crew members to get trained and up to speed on science experiments, maintenance work and other projects at the station. A SpaceX Falcon 9 rocket is prepared for launch at the Kennedy Space Center in Florida on Wednesday. (Craig Bailey / Reuters) After that, Williams, Wilmore, Hague and Gorbunov will travel home in the SpaceX Dragon capsule that Hague and Gorbunov flew to the space station in September. Two seats were purposefully kept empty so that their colleagues could later hitch a ride back to Earth. The Starliner spacecraft that Williams and Wilmore flew to space encountered several issues in June as it docked with the orbiting lab. After months of investigation and tests, NASA decided to bring the Starliner craft back to Earth with no one aboard and have the astronaut duo wait for a ride on a SpaceX vehicle instead. Their unexpectedly long stay in low-Earth orbit has recently become a political talking point. SpaceX CEO Elon Musk and President Donald Trump have both made unsubstantiated claims that the Biden administration held up the flight back to Earth for political reasons. Trump also said recently that he had tasked Musk with bringing the astronauts home. However, NASA has planned to use a SpaceX vehicle for their return journey since it was announced in August. This story first appeared on NBCNews.com. More from NBC News: A volcano near Alaska’s largest city could erupt in the coming weeks or months, scientists say EPA administrator announces huge rollback of environmental regulations Fossilized face fragments are oldest human ancestor remains ever found in Western Europe ...read more read less