Amy Schumer was diagnosed with Cushing syndrome, a hormonal disorder caused by high levels of cortisol in the body — thanks to comments from people on the internet who noticed her “puffier face,” she recently shared. Speaking on the “Call Her Daddy” podcast, she said that medical professionals addressing her online told her to seek medical attention for Cushing syndrome. “When I was going through, I guess it was like a year ago, and the internet really came for me after doing a bunch of press, and I was like, ‘OK, everybody like, relax,’” she recalled. “Doctors were chiming in in the comments and they were, like, ‘No, no … something’s really up. Your face looks so crazy.’” “And I’m like, wait, I’m getting trolled by doctors?” she continued. “They were like, ‘We think you have something called Cushing and it’s like, about spiking cortisol, about cortisol levels and steroids, injection whatever.” Oct 14, 2023 How is Bruce Willis' health? What to know about his Frontotemporal Dementia diagnosis Celebrity News Jun 29, 2024 Céline Dion makes surprise appearance at NHL Draft amid health battle Schumer went on to explain that the cause of her Cushing syndrome was steroid injections she was receiving to treat scars she had developed from her breast reduction and C-section. Her symptoms started right before beginning filming for her upcoming Netflix film, “Kinda Pregnant.” “Right before we started rolling was when I learned I had this condition and that I had something called moon face,” she said, adding that she worried her condition would become more severe and potentially life-threatening. “I was feeling really down on myself before I started filming this movie,” she said. But she’s since been treated and is feeling better. Schumer first revealed her Cushing syndrome diagnosis almost a year ago, in February 2024, in Jessica Yellin’s “News Not Noise“ newsletter. “While I was doing press on camera for my Hulu show, I was also in MRI machines four hours at a time, having my veins shut down from the amount of blood drawn and thinking I may not be around to see my son grow up,” Schumer said, after noting that she felt “reborn” by knowing her diagnosis. What is Cushing syndrome? Mayo Clinic describes Cushing syndrome as a condition that occurs when the body produces too much cortisol over a long period of time, or from taking glucocorticoid medicines. There are two types of Cushing syndrome: exogenous and endogenous. Exogenous Cushing syndrome is brought on by taking glucocorticoid medicines, which are typically used to treat inflammatory diseases and pain, according to the Mayo Clinic. This is the version Schumer was diagnosed with. Those who have endogenous Cushing syndrome have increased cortisol, which could have been a result of problems with the pituitary or adrenal glands, per the Mayo Clinic. If not treated, Cushing syndrome can lead to osteoporosis, high blood pressure, type 2 diabetes, infections and loss of muscle mass. What are the symptoms of Cushing syndrome? According to the Mayo Clinic, the following are common symptoms of Cushing syndrome for both men and women: Weight gain in the trunk of the body, accompanied by thin arms and legs Weight gain in the face, sometimes called “moon face” A fatty lump between the shoulders, sometimes called a “buffalo hump” Pink or purple stretch marks on the stomach, hips, thighs, breasts and underarms Thin, frail skin that bruises easily Slow wound healing Acne Women may experience a condition called hirsutism, which manifests as “thick, dark hair on the face and body,” as well as irregular periods or periods that stop. Men could experience lower sex drive, reduced fertility and problems getting an erection. Is Cushing syndrome fatal and what are the treatments? Cushing syndrome is treatable. The goal of treatment is to lower cortisol in the body, according to Mayo Clinic, which can involve lowering the use of glucocorticoid medicine, surgery, radiation therapy and medicine. Some medications used for treatment include ketoconazole, osilodrostat (Isturisa), mitotane (Lysodren), levoketoconazole (Recorlev), and metyrapone (Metopirone), mifepristone (Korlym, Mifeprex) and Pasireotide (Signifor). However, side effects for these medications could include tiredness, upset stomach, vomiting, headaches, muscle aches, high blood pressure, low potassium and swelling, per Mayo Clinic. More serious side effects include brain and nervous system side effects, as well as liver damage. What else has Amy Schumer said about her health? In a Feb. 15 Instagram post, the “Life & Beth” star reminded followers that she’s been diagnosed with endometriosis, which the Mayo Clinic describes as an often painful condition in which tissue that is similar to the inner lining of the uterus grows outside the uterus. In September 2021, Schumer revealed that she had her uterus and appendix removed due to endometriosis. The actor has also previously discussed her experience with hyperemesis gravidarum during her first pregnancy with her son, Gene, as well as her difficult delivery because of complications caused by endometriosis. In the News Not Noise newsletter, Schumer said she hopes to be an advocate for women’s health. “The shaming and criticism of our ever-changing bodies is something I have dealt with and witnessed for a long time,” she said. “I want so much for women to love themselves and be relentless when fighting for their own health in a system that usually doesn’t believe them.” This story first appeared on TODAY.com. More from TODAY: Savannah Guthrie on her new ‘Night Agent’ cameo and ‘method acting’ strategy Popular face moisturizer sold nationwide recalled, FDA says 2025 Oscar nominations: The biggest snubs and surprises