Copper radical mimics enzyme for highly efficient CH oxidation

Jan 15, 2025

Optically pure alcohols are prevalent motifs in natural products and pharmaceuticals, driving the development of effective methods for their synthesis. Since the first reports of the Kharasch-Sosnovsky reaction in 1958, the copper-catalyzed radical-mediated sp3 C-H oxidation has emerged as an important method for the selective oxidation of allylic, propargylic, and other sp3 C-H bonds.