The mosquito-borne Zika virus is known for causing microcephaly, a birth defect in which abnormal brain development results in a smaller-than-expected head. A new study shows that the Zika virus hijacks a host protein called ANKLE2, which happens to be important for brain development, to assist its own reproduction. Because Zika, unlike most related viruses, can cross the placenta, this can have disastrous consequences in pregnancy.