.................... LOS ANGELES (KTLA) - The worst-case scenario has been realized in the Pacific Palisades neighborhood of Los Angeles, where an estimated 1,000 structures, many of them homes, have been destroyed by a Santa Ana-wind-fueled wildfire, authorities confirmed on Wednesday morning. The Palisades Fire was first reported around 10:30 a.m. Tuesday in the 1100 block of North Piedra Morada Drive. By Wednesday morning, the fire had exploded to more than 5,000 acres with no containment. At a news conference Wednesday morning, L.A. County Fire Chief Anthony Marrone revealed that an estimated 1,000 structures had been lost. There was also a "high number of people who didn't evacuate" who suffered serious injuries. The Palisades Fire ravages a neighborhood amid high winds in the Pacific Palisades neighborhood of Los Angeles, Tuesday, Jan. 7, 2025. (AP Photo/Ethan Swope)Flames rise as the Palisades Fire advances on homes in the Pacific Palisades neighborhood of Los Angeles, Tuesday, Jan. 7, 2025. (AP Photo/Ethan Swope)Will Adams watches as flames from the Palisades Fire close in on his property in the Pacific Palisades neighborhood of Los Angeles, Tuesday, Jan. 7, 2025. (AP Photo/Ethan Swope)Water is dropped on the advancing Palisades Fire by helicopter in the Pacific Palisades neighborhood of Los Angeles, Tuesday, Jan. 7, 2025. (AP Photo/Ethan Swope)Plumes of smoke are seen as a brush fire burns in Pacific Palisades, California on January 7, 2025. (Getty Images)Plumes of smoke are seen as a brush fire burns in Pacific Palisades as seen from Santa Monica, California on January 7, 2025. (Getty Images)View of the Palisades Fire from LAX on Jan. 7, 2025. (KTLA)A palm tree is seen burning during the Palisades Fire in Los Angeles on Jan. 7, 2025. (KTLA)An ALERTCalifornia camera view of a brush fire in the Pacific Palisades area of Los Angeles County. Jan. 7, 2024. (ALERTCalifornia)A firefighter tries to extinguish a fire as it damages a property in the Pacific Palisades neighborhood of Los Angeles Tuesday, Jan. 7, 2025. (AP Photo)Firefighters work to extinguish flames engulfing a home as a brush fire rages in Pacific Palisades, California, on January 7, 2025. (Getty Images)A firefighter battles the Palisades Fire as it burns a structure in the Pacific Palisades neighborhood of Los Angeles, Tuesday, Jan. 7, 2025. (AP Photo/Ethan Swope)A firefighter jumps over a fence while fighting the Palisades Fire in the Pacific Palisades neighborhood of Los Angeles, Tuesday, Jan. 7, 2025. (AP Photo/Ethan Swope)The Palisades Fire burns a residence in the Pacific Palisades neighborhood of Los Angeles, Tuesday, Jan. 7, 2025. (AP Photo/Ethan Swope) Evacuations were ordered for the entire Palisades community down to the Pacific Ocean, according to CalFire. The evacuations, which also included warnings for Santa Monica and Calabasas areas, impacted tens of thousands of homes and businesses. An evacuation shelter for people and pets was established at the Westwood Recreation Center at 1350 S. Sepulveda Blvd. Santa Monica and Las Virgenes unified school districts canceled classes Wednesday. A map showing the location of the Palisades Fire and evacuation zones. Jan. 8, 2025. (CalFire) Dozens of Los Angeles County schools were closed Wednesday due to the fire. A number of schools in the Los Angeles Unified School District were also closed. The cause of the fire remains under investigation. Pacific Palisades is located about 10 miles from Malibu, where the Franklin Fire burned more than 4,000 acres and burned several homes after erupting during similar windy conditions in December. Palisades Fire Resources: LAFD Alerts | CALFIRE Incident Page | LAFD on X