INDIANAPOLIS — Interstate 65 was closed for four hours on the city's south side after a semi crashed and burst into flames — the fire claiming the driver's life. According to the Indiana Department of Transportation, the vehicle fire occurred at 10:40 a.m. near mile marker 102.9 on the southbound side of Interstate 65. This is on the city's south side near the Southport Road exit. Deadly vehicle fire on I-65 on Dec. 19, 2025. (INDOT camera) Indianapolis Fire Department confirmed a semi-truck driver died in the fire after his truck left the roadway, crashed into several interstate signs and a guardrail before bursting into flames. The driver was a 60-year-old man and was hauling wood pallets. Deadly semi fire closed I-65 near Southport Road. (Indiana State Police) Aftermath of the deadly semi truck fire on I-65. Firefighters had extreme difficulties combating the fire due to water supply issues as no hydrants were nearby, IFD said. Water tankers were deployed but it took 45 minutes before the fire was marked under control. For another 45 minutes, firefighters fought with hot spots until the fire was at last marked as terminated at 2:25 p.m. All lanes of southbound traffic were completely closed for several hours as a result of the crash. INDOT maps show that northbound traffic was also affected by long delays and congestion because of the incident. Around 3 p.m., one lane on southbound Interstate 65 was opened after the burned remains of the truck were finally cleared from the roadway. Photos from the deadly semi fire on I-65 near Southport Rd on Dec. 19, 2024. (IFD)Photos from the deadly semi fire on I-65 near Southport Rd on Dec. 19, 2024. (IFD)Photos from the deadly semi fire on I-65 near Southport Rd on Dec. 19, 2024. (IFD)Photos from the deadly semi fire on I-65 near Southport Rd on Dec. 19, 2024. (IFD)Photos from the deadly semi fire on I-65 near Southport Rd on Dec. 19, 2024. (IFD) ISP Sgt. John Perrine said the southbound closure would be "very extended" and asked drivers for patience. This is a developing story. Check back for updates.