Wondering about the best against-the-spread bet among all 16 NFL games in Week 16? Our choice, in terms of ATS, is Raiders -1. But continue reading, because we have lots more suggestions, and that could lead to parlay opportunities. Find an edge on the competition and take advantage of our spread picks for the NFL. BetMGM has all the information you need to start wagering on the NFL. NFL Picks Against the Spread – Week 16 Jump to Matchup: JAX-LV | SF-MIA | DEN-LAC | HOU-KC | MIN-SEA | PHI-WAS | LAR-NYJ | TEN-IND | ARI-CAR | TB-DAL | PIT-BAL | DET-CHI | CLE-CIN | NYG-ATL | NO-GB | NE-BUF Pick: Raiders -1 vs. Jaguars Matchup: Jacksonville Jaguars at Las Vegas Raiders Projected Winner & Margin: Raiders by 1.1 points (Bet on this game at BetMGM) Spread: Raiders -1 Time: 4:25 p.m. ET Date: Dec. 22 TV Channel: CBS Live Stream: Paramount+ | Fubo (Regional restrictions may apply) Pick: 49ers +1 vs. Dolphins Matchup: San Francisco 49ers at Miami Dolphins Projected Winner & Margin: 49ers by 1.5 points (Bet on this game at BetMGM) Spread: Dolphins -1 Time: 4:25 p.m. ET Date: Dec. 22 TV Channel: CBS Live Stream: Paramount+ | Fubo (Regional restrictions may apply) Pick: Broncos +2.5 vs. Chargers Matchup: Denver Broncos at Los Angeles Chargers Projected Winner & Margin: Broncos by 0.7 points (Bet on this game at BetMGM) Spread: Chargers -2.5 Time: 8:15 p.m. ET Date: Dec. 19 TV Channel: Amazon Prime Video Live Stream: Watch this game on Prime Video (Regional restrictions may apply) Pick: Chiefs -3 vs. Texans Matchup: Houston Texans at Kansas City Chiefs Projected Winner & Margin: Chiefs by 7.2 points (Bet on this game at BetMGM) Spread: Chiefs -3 Time: 1 p.m. ET Date: Dec. 21 TV Channel: NBC Live Stream: Watch this game on Fubo (Regional restrictions may apply) Pick: Vikings -3 vs. Seahawks Matchup: Minnesota Vikings at Seattle Seahawks Projected Winner & Margin: Vikings by 4.6 points (Bet on this game at BetMGM) Spread: Vikings -3 Time: 4:05 p.m. ET Date: Dec. 22 TV Channel: FOX Live Stream: Watch this game on Fubo (Regional restrictions may apply) Pick: Eagles -3.5 vs. Commanders Matchup: Philadelphia Eagles at Washington Commanders Projected Winner & Margin: Eagles by 4.1 points (Bet on this game at BetMGM) Spread: Eagles -3.5 Time: 1 p.m. ET Date: Dec. 22 TV Channel: FOX Live Stream: Watch this game on Fubo (Regional restrictions may apply) Pick: Rams -3.5 vs. Jets Matchup: Los Angeles Rams at New York Jets Projected Winner & Margin: Rams by 4.3 points (Bet on this game at BetMGM) Spread: Rams -3.5 Time: 1 p.m. ET Date: Dec. 22 TV Channel: CBS Live Stream: Paramount+ | Fubo (Regional restrictions may apply) Pick: Colts -3.5 vs. Titans Matchup: Tennessee Titans at Indianapolis Colts Projected Winner & Margin: Colts by 11.0 points (Bet on this game at BetMGM) Spread: Colts -3.5 Time: 1 p.m. ET Date: Dec. 22 TV Channel: CBS Live Stream: Paramount+ | Fubo (Regional restrictions may apply) Pick: Cardinals -4 vs. Panthers Matchup: Arizona Cardinals at Carolina Panthers Projected Winner & Margin: Cardinals by 14.5 points (Bet on this game at BetMGM) Spread: Cardinals -4 Time: 1 p.m. ET Date: Dec. 22 TV Channel: FOX Live Stream: Watch this game on Fubo (Regional restrictions may apply) Pick: Buccaneers -4 vs. Cowboys Matchup: Tampa Bay Buccaneers at Dallas Cowboys Projected Winner & Margin: Buccaneers by 12.5 points (Bet on this game at BetMGM) Spread: Buccaneers -4 Time: 8:20 p.m. ET Date: Dec. 22 TV Channel: NBC Live Stream: Watch this game on Fubo (Regional restrictions may apply) Pick: Ravens -6 vs. Steelers Matchup: Pittsburgh Steelers at Baltimore Ravens Projected Winner & Margin: Ravens by 6.7 points (Bet on this game at BetMGM) Spread: Ravens -6 Time: 4:30 p.m. ET Date: Dec. 21 TV Channel: FOX Live Stream: Watch this game on Fubo (Regional restrictions may apply) Pick: Lions -6.5 vs. Bears Matchup: Detroit Lions at Chicago Bears Projected Winner & Margin: Lions by 17.6 points (Bet on this game at BetMGM) Spread: Lions -6.5 Time: 1 p.m. ET Date: Dec. 22 TV Channel: FOX Live Stream: Watch this game on Fubo (Regional restrictions may apply) Pick: Bengals -7.5 vs. Browns Matchup: Cleveland Browns at Cincinnati Bengals Projected Winner & Margin: Bengals by 10.6 points (Bet on this game at BetMGM) Spread: Bengals -7.5 Time: 1 p.m. ET Date: Dec. 22 TV Channel: CBS Live Stream: Paramount+ | Fubo (Regional restrictions may apply) Pick: Falcons -8.5 vs. Giants Matchup: New York Giants at Atlanta Falcons Projected Winner & Margin: Falcons by 11.9 points (Bet on this game at BetMGM) Spread: Falcons -8.5 Time: 1 p.m. ET Date: Dec. 22 TV Channel: FOX Live Stream: Watch this game on Fubo (Regional restrictions may apply) Pick: Packers -13.5 vs. Saints Matchup: New Orleans Saints at Green Bay Packers Projected Winner & Margin: Packers by 18.1 points (Bet on this game at BetMGM) Spread: Packers -13.5 Time: 8:15 p.m. ET Date: Dec. 23 TV Channel: ESPN Live Stream: Watch this game on Fubo (Regional restrictions may apply) Pick: Bills -14 vs. Patriots Matchup: New England Patriots at Buffalo Bills Projected Winner & Margin: Bills by 24.6 points (Bet on this game at BetMGM) Spread: Bills -14 Time: 4:25 p.m. ET Date: Dec. 22 TV Channel: CBS Live Stream: Paramount+ | Fubo (Regional restrictions may apply) Catch every NFL touchdown with NFL RedZone on Fubo. Not all offers available in all states, please visit BetMGM for the latest promotions for your area. Must be 21+ to gamble, please wager responsibly. If you or someone you know has a gambling problem, contact 1-800-GAMBLER. The post NFL Week 16 Picks Against the Spread, Tips and Predictions appeared first on Austin Daily Herald.