On the Week 16 NFL schedule, we have the Lions (-6.5) as the best bet on the board. Scroll down for more tips on point spreads and totals, including parlay possibilities. Take advantage of our predictions to make your NFL picks this week. BetMGM has all the information you need to begin betting on the NFL. Best Week 16 Spread Bets Jump to Matchup: JAX-LV | SF-MIA | DEN-LAC | HOU-KC | MIN-SEA Pick: Raiders -1 vs. Jaguars Matchup: Jacksonville Jaguars at Las Vegas Raiders Projected Winner & Margin: Raiders by 1.1 points (Bet on this game at BetMGM) Spread: Raiders -1 Time: 4:25 p.m. ET Date: Dec. 22 TV Channel: CBS Live Stream: Paramount+ | Fubo (Regional restrictions may apply) Pick: 49ers +1 vs. Dolphins Matchup: San Francisco 49ers at Miami Dolphins Projected Winner & Margin: 49ers by 1.5 points (Bet on this game at BetMGM) Spread: Dolphins -1 Time: 4:25 p.m. ET Date: Dec. 22 TV Channel: CBS Live Stream: Paramount+ | Fubo (Regional restrictions may apply) Pick: Broncos +2.5 vs. Chargers Matchup: Denver Broncos at Los Angeles Chargers Projected Winner & Margin: Broncos by 0.7 points (Bet on this game at BetMGM) Spread: Chargers -2.5 Time: 8:15 p.m. ET Date: Dec. 19 TV Channel: Amazon Prime Video Live Stream: Watch this game on Prime Video (Regional restrictions may apply) Pick: Chiefs -3 vs. Texans Matchup: Houston Texans at Kansas City Chiefs Projected Winner & Margin: Chiefs by 7.2 points (Bet on this game at BetMGM) Spread: Chiefs -3 Time: 1 p.m. ET Date: Dec. 21 TV Channel: NBC Live Stream: Watch this game on Fubo (Regional restrictions may apply) Pick: Vikings -3 vs. Seahawks Matchup: Minnesota Vikings at Seattle Seahawks Projected Winner & Margin: Vikings by 4.6 points (Bet on this game at BetMGM) Spread: Vikings -3 Time: 4:05 p.m. ET Date: Dec. 22 TV Channel: FOX Live Stream: Watch this game on Fubo (Regional restrictions may apply) Make smart decisions. Use those stats when making your NFL picks and place your bet on BetMGM. Best Week 16 Total Bets Jump to Matchup: PHI-WAS | MIN-SEA | PIT-BAL | HOU-KC | DET-CHI Over 45.5 – Eagles vs. Commanders Matchup: Philadelphia Eagles at Washington Commanders Projected Total: 47.4 points (Bet on this game at BetMGM) Time: 1 p.m. ET Date: Dec. 22 TV Channel: FOX Live Stream: Watch this game on Fubo (Regional restrictions may apply) Over 42.5 – Vikings vs. Seahawks Matchup: Minnesota Vikings at Seattle Seahawks Projected Total: 44.6 points (Bet on this game at BetMGM) Time: 4:05 p.m. ET Date: Dec. 22 TV Channel: FOX Live Stream: Watch this game on Fubo (Regional restrictions may apply) Over 45 – Steelers vs. Ravens Matchup: Pittsburgh Steelers at Baltimore Ravens Projected Total: 48.3 points (Bet on this game at BetMGM) Time: 4:30 p.m. ET Date: Dec. 21 TV Channel: FOX Live Stream: Watch this game on Fubo (Regional restrictions may apply) Over 41.5 – Texans vs. Chiefs Matchup: Houston Texans at Kansas City Chiefs Projected Total: 43.4 points (Bet on this game at BetMGM) Time: 1 p.m. ET Date: Dec. 21 TV Channel: NBC Live Stream: Watch this game on Fubo (Regional restrictions may apply) Under 48 – Lions vs. Bears Matchup: Detroit Lions at Chicago Bears Projected Total: 47.0 points (Bet on this game at BetMGM) Time: 1 p.m. ET Date: Dec. 22 TV Channel: FOX Live Stream: Watch this game on Fubo (Regional restrictions may apply) Catch every NFL touchdown with NFL RedZone on Fubo. Not all offers available in all states, please visit BetMGM for the latest promotions for your area. Must be 21+ to gamble, please wager responsibly. If you or someone you know has a gambling problem, contact 1-800-GAMBLER. The post NFL Week 16 Computer Predictions, Best Bets, Over/Under Picks appeared first on Austin Daily Herald.