A study is the first-of-its-kind to recognize American Sign Language (ASL) alphabet gestures using computer vision. Researchers developed a custom dataset of 29,820 static images of ASL hand gestures. Each image was annotated with 21 key landmarks on the hand, providing detailed spatial information about its structure and position. Combining MediaPipe and YOLOv8, a deep learning method they trained, with fine-tuning hyperparameters for the best accuracy, represents a groundbreaking and innovative approach that hasn't been explored in previous research.