COLUMBUS, Ohio (WCMH) -- In a game with postseason implications, No. 2 Ohio State plays No. 5 Indiana at Ohio Stadium on Saturday, looking to keep hopes of a Big Ten title alive. The Hoosiers (10-0) are the third top-five opponent that the Buckeyes have faced. They previously lost to then-No. 3 Oregon before beating then-No. 3 Penn State last month. Both of those games were on the road. Ohio State enters the game with changes to the offensive line after graduate transfer Seth McLaughlin suffered a season-ending injury in practice earlier this week. Carson Hinzman will take McLaughlin's place at center, and Austin Siereveld will move to left guard. NFL announces schedule change for Bengals, Browns game in December The winner of the game will essentially have a firm grasp of a spot in the Big Ten championship game next month. The Ducks have already clinched a spot for the game Dec. 7 in Indianapolis. Scroll below for live updates.