Cryoelectron microscopy sheds light on endothelin signaling mechanisms

Oct 17, 2024

Endothelin is a peptide hormone known for its vasoconstrictive effects. Researchers at University of Tsukuba used cryo-electron microscopy to examine the complex structure of the endothelin receptor and G protein, which are crucial for signal transduction at the cell membrane. This study has clarified the mechanism of signal transduction between cells.