There are 14 matchups on the NFL’s Week 6 schedule, with the Titans (+1) among the best bets against the spread, according to our projections. For more tips, including parlay opportunities, keep reading. Find an edge on the competition and take advantage of our spread picks for the NFL. BetMGM has all the information you need to start wagering on the NFL. NFL Picks Against the Spread – Week 6 Jump to Matchup: IND-TEN | JAX-CHI | BUF-NYJ | LAC-DEN | PIT-LV | SF-SEA | TB-NO | DET-DAL | CIN-NYG | ARI-GB | ATL-CAR | WAS-BAL | HOU-NE | CLE-PHI Pick: Titans +1 vs. Colts Matchup: Indianapolis Colts at Tennessee Titans Projected Winner & Margin: Colts by 0.6 points (Bet on this game at BetMGM) Spread: Colts -1 Time: 1:00 p.m. ET Date: Oct. 13 TV Channel: CBS Live Stream: Paramount+ | Fubo (Regional restrictions may apply) Pick: Bears -2.5 vs. Jaguars Matchup: Jacksonville Jaguars vs. Chicago Bears Projected Winner & Margin: Bears by 13.5 points (Bet on this game at BetMGM) Spread: Bears -2.5 Time: 9:30 a.m. ET Date: Oct. 13 TV Channel: NFL Network Live Stream: Watch this game on Fubo (Regional restrictions may apply) Pick: Jets +2.5 vs. Bills Matchup: Buffalo Bills at New York Jets Projected Winner & Margin: Jets by 3.2 points (Bet on this game at BetMGM) Spread: Bills -2.5 Time: 8:15 p.m. ET Date: Oct. 14 TV Channel: ESPN Live Stream: Watch this game on Fubo (Regional restrictions may apply) Pick: Broncos +3 vs. Chargers Matchup: Los Angeles Chargers at Denver Broncos Projected Winner & Margin: Broncos by 6.4 points (Bet on this game at BetMGM) Spread: Chargers -3 Time: 4:05 p.m. ET Date: Oct. 13 TV Channel: CBS Live Stream: Paramount+ | Fubo (Regional restrictions may apply) Pick: Steelers -3 vs. Raiders Matchup: Pittsburgh Steelers at Las Vegas Raiders Projected Winner & Margin: Steelers by 8.7 points (Bet on this game at BetMGM) Spread: Steelers -3 Time: 4:05 p.m. ET Date: Oct. 13 TV Channel: CBS Live Stream: Paramount+ | Fubo (Regional restrictions may apply) Pick: Seahawks +3.5 vs. 49ers Matchup: San Francisco 49ers at Seattle Seahawks Projected Winner & Margin: Seahawks by 1.0 points (Bet on this game at BetMGM) Spread: 49ers -3.5 Time: 8:15 p.m. ET Date: Oct. 10 TV Channel: Amazon Prime Video Live Stream: Watch this game on Prime Video (Regional restrictions may apply) Pick: Saints +3.5 vs. Buccaneers Matchup: Tampa Bay Buccaneers at New Orleans Saints Projected Winner & Margin: Saints by 0.2 points (Bet on this game at BetMGM) Spread: Buccaneers -3.5 Time: 1:00 p.m. ET Date: Oct. 13 TV Channel: FOX Live Stream: Watch this game on Fubo (Regional restrictions may apply) Pick: Cowboys +3.5 vs. Lions Matchup: Detroit Lions at Dallas Cowboys Projected Winner & Margin: Cowboys by 3.1 points (Bet on this game at BetMGM) Spread: Lions -3.5 Time: 4:25 p.m. ET Date: Oct. 13 TV Channel: FOX Live Stream: Watch this game on Fubo (Regional restrictions may apply) Pick: Giants +3.5 vs. Bengals Matchup: Cincinnati Bengals at New York Giants Projected Winner & Margin: Giants by 5.7 points (Bet on this game at BetMGM) Spread: Bengals -3.5 Time: 8:20 p.m. ET Date: Oct. 13 TV Channel: NBC Live Stream: Watch this game on Fubo (Regional restrictions may apply) Pick: Packers -5 vs. Cardinals Matchup: Arizona Cardinals at Green Bay Packers Projected Winner & Margin: Packers by 9.6 points (Bet on this game at BetMGM) Spread: Packers -5 Time: 1:00 p.m. ET Date: Oct. 13 TV Channel: FOX Live Stream: Watch this game on Fubo (Regional restrictions may apply) Pick: Falcons -6 vs. Panthers Matchup: Atlanta Falcons at Carolina Panthers Projected Winner & Margin: Falcons by 17.2 points (Bet on this game at BetMGM) Spread: Falcons -6 Time: 4:25 p.m. ET Date: Oct. 13 TV Channel: FOX Live Stream: Watch this game on Fubo (Regional restrictions may apply) Pick: Commanders +6.5 vs. Ravens Matchup: Washington Commanders at Baltimore Ravens Projected Winner & Margin: Commanders by 0.4 points (Bet on this game at BetMGM) Spread: Ravens -6.5 Time: 1:00 p.m. ET Date: Oct. 13 TV Channel: CBS Live Stream: Paramount+ | Fubo (Regional restrictions may apply) Pick: Texans -7 vs. Patriots Matchup: Houston Texans at New England Patriots Projected Winner & Margin: Texans by 11.0 points (Bet on this game at BetMGM) Spread: Texans -7 Time: 1:00 p.m. ET Date: Oct. 13 TV Channel: CBS Live Stream: Paramount+ | Fubo (Regional restrictions may apply) Pick: Eagles -8.5 vs. Browns Matchup: Cleveland Browns at Philadelphia Eagles Projected Winner & Margin: Eagles by 20.0 points (Bet on this game at BetMGM) Spread: Eagles -8.5 Time: 1:00 p.m. ET Date: Oct. 13 TV Channel: FOX Live Stream: Watch this game on Fubo (Regional restrictions may apply) Catch every NFL touchdown with NFL RedZone on Fubo. 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