INDIANAPOLIS — Jacksonville's EverBank Stadium continues to be a "house of horrors" for the Colts. The Jaguars won their first game of the season on Sunday, beating Indianapolis, 37-34. Jaguars' kicker Cam Little made a 49-yard field goal with 17 seconds left to help Jacksonville clinch its victory. The Colts have not won on the road in Jacksonville since Andrew Luck threw four touchdowns in a 44-17 rout in 2014. Backup quarterback Joe Flacco filled in admirably for starter Anthony Richardson, rallying the team from a 14-point deficit late in the fourth quarter to tie the game. Richardson sat out with an oblique injury he suffered last week against Pittsburgh. Flacco finished 33-of-44 for 359 yards, three touchdowns and no interceptions. The Colts took an early lead, driving 71 yards in 12 plays for the first points of the game. Flacco connected with wide receiver Michael Pittman Jr. on a fourth-and-goal from the 1-yard line for a touchdown. The Colts' defense made a stop on Jacksonville's first possession, as quarterback Trevor Lawrence threw an incompletion on fourth-and-2 from the Indianapolis 26-yard line to turn the ball over on downs. The Colts' defense held strong on the Jaguars' next possession, limiting Jacksonville to a field goal after it drove to the 4-yard line. Indy's defense broke the third time Jacksonville had the ball, as Lawrence hit rookie wide receiver Brian Thomas for an 85-yard touchdown and a 10-7 lead. The Colts tied the game on a Matt Gay 30-yard field goal. Then, Jacksonville generated a score off a turnover before the end of the first half. Jaguars' defensive end Travon Walker stripped Flacco. Defensive lineman Josh Hines-Allen recovered and returned the ball to the Indianapolis 12-yard line with six seconds left in the half. Little kicked a 30-yard field goal on the next play to send Jacksonville to the locker room with a 13-10 advantage. The teams exchanged punts to start the second half with a Nick Cross interception of Lawrence mixed in before the offenses exploded. Jaguars running back Tank Bigsby scored from 19 yards out to make it 20-10. The Colts answered with an 18-yard scoring strike from Flacco to tight end Mo Alie-Cox. Lawrence found tight end Brenton Strange for a four-yard touchdown to make it 27-17. The Colts responded with a Gay 37-yard field goal to keep it a one-possession game. Bigsby broke free for a 65-yard touchdown run to extend Jacksonville's lead to 34-20, but the Colts refused to quit. Flacco and wide receiver Alec Pierce connected for a 46-yard gain down to the Jaguars' one-yard line. Colts running back Trey Sermon scored on the next play to cut the deficit to 34-27. The defense forced a three-and-out before Flacco found Pierce for another huge play — a 65-yard touchdown to tie the game at 34 with 2:40 left in the fourth quarter. Lawrence drove Jacksonville 39 yards in eight plays to set up Little's game-winning field goal. Colts' starting right guard Will Fries appeared to suffer a serious injury in the third quarter. He had to be taken off the field on a cart. His teammates surrounded him in support as he left for the locker room. Undrafted free agent Dalton Tucker filled his spot on the offensive line. Running back Jonathan Taylor (ankle), center Ryan Kelly (neck), cornerback Kenny Moore II (hip) and defensive end Kwity Paye (quadricep) also missed the game with injuries. The Colts will play their second straight divisional road game when they visit the Tennessee Titans next Sunday at 1:00 p.m. on CBS4.