Proteomics method identifies ligandbinding proteins and binding sites in complex systems

Dec 13, 2024

In a study published in Nature Methods, a research group developed a highly sensitive proteomics method called peptide-centric local stability assay (PELSA), which enables the simultaneous identification of ligand-binding proteins and their binding sites in complex systems. PELSA is broadly applicable to diverse ligands including metabolites, drugs, and pollutants.